Alexander Fletcher

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  Cell-based modelling of epithelial morphogenesis
  Alexander Fletcher

  Embryonic epithelia achieve complex morphogenetic movements through the coordinated action and rearrangement of individual cells. In combination with experimental approaches, computational modelling can provide insight into these processes. In this talk I describe our application of vertex models, a widely-used class of computational model for epithelia, to investigate the role of patterned cell mechanics in two settings in the Drosophila embryo: tissue size control and convergent extension. I highlight the biological insights gained through this work and conclude by presenting some recent extensions to 3D morphogenesis.